The experimental and clinical pharmacology of St John's Wort (Hypericum perforatum L.)
نویسندگان
چکیده
منابع مشابه
St John's wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties.
The chemical composition of St. John's wort has been well-studied. Documented pharmacological activities, including antidepressant, antiviral, and antibacterial effects, provide supporting evidence for several of the traditional uses stated for St John's wort. Many pharmacological activities appear to be attributable to hypericin and to the flavonoid constituents; hypericin is also reported to ...
متن کاملSt. John's wort (Hypericum perforatum) and warfarin: Dangerous liaisons!
An 85-year-old male patient with a history of hypertension, old anterior wall myocardial infarction and atrial fibrillation was placed on warfarin one year previously. However, he did not comply with regular international normalized ratio (INR) measurements, but kept taking warfarin (5 mg) on a daily basis for almost a year without any problems. After watching a television program about herbal ...
متن کاملSt John’s wort (Hypericum perforatum)-induced psychosis: a case report
BACKGROUND St John's wort (Hypericum perforatum) has been known for centuries for its therapeutic properties and its efficacy as an antidepressant has been confirmed by a growing body of evidence. During the last two decades it has also come to prominence with a wider public, due to advertising efforts across Europe and United States of America. However, its availability without prescription, a...
متن کاملPharmacokinetic interactions of Hypericum perforatum L. (St John's wort) with conventional drugs: a review of clinical studies
Background and objectives: Hypericum perforatum L., commonly known as St. John’s wort (SJW) from the family Hypericaceae is a famous medicinal plant used to treat mild to moderate depression; so, it might affect the pharmacokinetics of numerous drugs. Due to widespread herb-drug interactions of SJW, this study was designed to review the clinical evidences regarding the...
متن کاملEffects of St John's wort (Hypericum perforatum L.) extracts on epileptogenesis.
The purpose of this study was to investigate the effects of treatment with water, n-butanol and ether extracts of Hypercom perforatum L. on epileptogenesis in rabbits. Animals from the control group received solvent-ethanol, and the kindling model of epilepsy was used. Epileptic focus was induced in Chinchilla rabbits by stimulation of the hippocampus. The following parameters were determined: ...
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ژورنال
عنوان ژورنال: Molecular Psychiatry
سال: 1999
ISSN: 1359-4184,1476-5578
DOI: 10.1038/sj.mp.4000557